Article
A role for ATR in the DNA damage-induced phosphorylation of p53.
Genes & development - 15 Jan 1999
Tibbetts R S, Brumbaugh K M, Williams J M, Sarkaria J N, Cliby W A, Shieh S Y, Taya Y, Prives C, Abraham R T
Abstract excerpt
Phosphorylation at Ser-15 may be a critical event in the up-regulation and functional activation of p53 during cellular stress. In this report we provide evidence that the ATM-Rad3-related protein ATR regulates phosphorylation of Ser-15 in DNA-damaged cells. Overexpression of catalytically inacti...
Topics
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle Proteins
- DNA Damage
- DNA-Binding Proteins
- Doxycycline
- Fibroblasts
- Gamma Rays
- Humans
- K562 Cells
- Mutation
- Phosphorylation
- Precipitin Tests
- Protein Serine-Threonine Kinases
- Proteins
- Recombinant Fusion Proteins