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Article

A role for ATR in the DNA damage-induced phosphorylation of p53.

Genes & development - 15 Jan 1999

Tibbetts R S, Brumbaugh K M, Williams J M, Sarkaria J N, Cliby W A, Shieh S Y, Taya Y, Prives C, Abraham R T

Abstract excerpt

Phosphorylation at Ser-15 may be a critical event in the up-regulation and functional activation of p53 during cellular stress. In this report we provide evidence that the ATM-Rad3-related protein ATR regulates phosphorylation of Ser-15 in DNA-damaged cells. Overexpression of catalytically inactive ATR (ATRki) in human fibroblasts inhibited Ser-15 phosphorylation in response to gamma-irradiation and UV light. In...

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Source

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Identifiers

PMID: 9925639
DOI: 10.1101/gad.13.2.152
PMCID: PMC316393

Genes

ATR
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A role for ATR in the DNA damage-induced phosphorylation of p53.PMID 9925639Read ↗

Hypoxia Links ATR and p53 through Replication ArrestSemantic proximity Read ↗

Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV.Semantic proximity Read ↗

Enhanced phosphorylation of p53 by ATM in response to DNA damage.Semantic proximity Read ↗

Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants.Semantic proximity Read ↗

Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters.Semantic proximity Read ↗

Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A.Semantic proximity Read ↗

ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responsesSemantic proximity Read ↗

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.Semantic proximity Read ↗

ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation.Semantic proximity Read ↗

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Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53.Semantic proximity Read ↗

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