Article
Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53.
Oncogene - 23 Aug 2001
Turenne G A, Paul P, Laflair L, Price B D
Abstract excerpt
The ATM protein kinase regulates the cell's response to DNA damage by regulating cell cycle checkpoints and DNA repair. ATM phosphorylates several proteins involved in the DNA-damage response, including p53. We have examined the mechanism by which ATM regulates p53's transcriptional activity. Here, we demonstrate that reintroduction of ATM into AT cells restores the activation of p53 by the radio-mimetic agent...
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