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Article

p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

Nature cell biology - 1 May 2007

Song Hoseok, Hollstein Monica, Xu Yang

Abstract excerpt

Tp53 is the most commonly mutated tumour-suppressor gene in human cancers. In addition to the loss of tumour-suppression function, some missense mutants gain novel oncogenic activities. To elucidate the nature of the gain of function, we introduced the most common p53 cancer mutations (R248W and...

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Source

Identifiers

PMID: 17417627
DOI: 10.1038/ncb1571

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17417627-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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