Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV.

Oncogene - 1 Mar 2001

Bean L J, Stark G R

Abstract excerpt

Changes in the phosphorylation state of p53 are important in increasing its half-life and potency as a transcription factor. To investigate their roles, serine residues 15 and 37 were mutated to alanines and the mutated proteins were expressed stably at low basal levels in Li-Fraumeni-derived p53...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to Cyclin-Dependent Kinase Inhibitor p21
Share to Cyclins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Doxorubicin

Share to Precipitin Tests

Share to Proto-Oncogene Proteins c-mdm2

Share to Serine

Share to Ultraviolet Rays

Source

Identifiers

PMID: 11314044
DOI: 10.1038/sj.onc.1204204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11314044-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV.PMID 11314044Read ↗

Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters.Semantic proximity Read ↗

A role for ATR in the DNA damage-induced phosphorylation of p53.Semantic proximity Read ↗

Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination.Semantic proximity Read ↗

Mutant p53 is constitutively phosphorylated at Serine 15 in UV-induced mouse skin tumors: involvement of ERK1/2 MAP kinase.Semantic proximity Read ↗

ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation.Semantic proximity Read ↗

Modifications of p53 and the DNA damage response in cells expressing mutant form of the protein huntingtin.Semantic proximity Read ↗

Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53.Semantic proximity Read ↗

Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants.Semantic proximity Read ↗

Posttranslational Modifications of p53 in Replicative Senescence Overlapping but Distinct from Those Induced by DNA DamageSemantic proximity Read ↗

p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.Semantic proximity Read ↗

Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes.Semantic proximity Read ↗

Blockage of NF-kappaB induces serine 15 phosphorylation of mutant p53 by JNK kinase in prostate cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.