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Article

Strain-specific spontaneous and NNK-mediated tumorigenesis in Pten+/- mice.

Neoplasia (New York, N.Y.) - 1 Aug 2008

Hollander Mary Christine, Balogh Andria R, Liwanag Jaminelli, Han Wei, Linnoila Ritva Ilona, Anver Miriam R, Dennis Phillip A

Abstract excerpt

Pten is a negative regulator of the Akt pathway, and its inactivation is believed to be an etiological factor in many tumor types. Pten+/- mice are susceptible to a variety of spontaneous tumor types, depending on strain background. Pten+/- mice, in lung tumor-sensitive and -resistant background strains, were treated with a tobacco carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), to determine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, ras

Share to Injections, Intraperitoneal

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Share to Proto-Oncogene Proteins c-akt

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Source

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Identifiers

PMID: 18683321
DOI: 10.1593/neo.08406
PMCID: PMC2504769

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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