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Article

Genetic background controls tumor development in PTEN-deficient mice.

Cancer research - 1 Jul 2006

Freeman Dan, Lesche Ralf, Kertesz Nathalie, Wang Shungyou, Li Gang, Gao Jing, Groszer Matthias, Martinez-Diaz Hilda, Rozengurt Nora, Thomas George, Liu Xin, Wu Hong

Abstract excerpt

PTEN is one of the most frequently mutated tumor suppressor genes in human cancers. Germ line mutations of PTEN have been detected in three rare autosomal-dominant disorders. However, identical mutations in the PTEN gene may lead to different symptoms that have traditionally been described as different disorders, such as Cowden disease, Lhermitte-Duclos disease, and Bannayan-Zonana syndromes. This lack of...

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Source

Identifiers

PMID: 16818619
DOI: 10.1158/0008-5472.CAN-05-4143

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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