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Article

Activation of MEK1/2-ERK1/2 signaling during NNK-induced lung carcinogenesis in female A/J mice.

Cancer medicine - 1 May 2016

Yamakawa Keiko, Yokohira Masanao, Nakano Yuko, Kishi Sosuke, Kanie Shohei, Imaida Katsumi

Abstract excerpt

The extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway is activated by several growth factors and mitogens, and upregulation has been noted in many human cancers, including examples in the lung. In this study, to study the association of ERK1/2 activation with mutation of Kras encoding an upstream activator of ERK1/2 in lung premalignant lesions, we immunohistochemically examined expression of...

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Identifiers

PMID: 26864819
DOI: 10.1002/cam4.652
PMCID: PMC4864820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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