Article
Allele-specific activation and expression of the K-ras gene in hybrid mouse lung tumors induced by chemical carcinogens.
Carcinogenesis - 1 Sept 1994
Chen B, You L, Wang Y, Stoner G D, You M
Abstract excerpt
A mouse hybrid, (C3H x A/J)F1 or C3A, was developed by crossing male A/J mice (high lung tumor susceptibility) with female C3H mice (low lung tumor susceptibility). The lung tumor responses of the C3A mice to dimethylnitrosamine (DMN) or benzo[a]pyrene (B[a]P) were found to be intermediate between those of the two parental strains. Mutational activation of the K-ras gene was found at a high frequency in both the...
Topics
- Alleles
- Animals
- Cocarcinogenesis
- Dimethylnitrosamine
- Female
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Lung Neoplasms
- Male
- Mice
- Mice, Inbred A
- Mice, Inbred C3H