Article
AKT1E¹⁷K Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer.
PloS one - 1 Jan 2016
Malanga Donatella, Belmonte Stefania, Colelli Fabiana, Scarfò Marzia, De Marco Carmela, Oliveira Duarte Mendes, Mirante Teresa, Camastra Caterina, Gagliardi Monica, Rizzuto Antonia, Mignogna Chiara, Paciello Orlando, Papparella Serenella, Fagman Henrik, Viglietto Giuseppe
Abstract excerpt
The hotspot AKT1E17K mutation in the pleckstrin homology domain of AKT1 occurs in approximately 0.6-2% of human lung cancers. Recently, we have demonstrated that AKT1E17K transforms immortalized human bronchial cells. Here by use of a transgenic Cre-inducible murine strain in the wild type Rosa26 (R26) locus (R26-AKT1E17K mice) we demonstrate that AKT1E17K is a bona-fide oncogene and plays a role in the...
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