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Article

Isoform-Specific Effects of Wild-Type Ras Genes on Carcinogen-Induced Lung Tumorigenesis in Mice.

PloS one - 1 Jan 2016

Weyandt Jamie D, Carney John M, Pavlisko Elizabeth N, Xu MengMeng, Counter Christopher M

Abstract excerpt

The gene KRAS is commonly mutated in lung cancer to encode a constitutively active and oncogenic protein that is well established to initiate and maintain lung tumorigenesis. However, the remaining wild-type KRAS protein, or the other family members HRAS and NRAS, can still be activated in the presence of oncogenic KRAS. Moreover, loss of any one of these three genes has been shown to increase the sensitivity of...

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Source

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Identifiers

PMID: 27911940
DOI: 10.1371/journal.pone.0167205
PMCID: PMC5135096

Genes

KRAS
HRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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