Article
Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer.
Cancer research - 15 Feb 2008
Iwanaga Kentaro, Yang Yanan, Raso Maria Gabriela, Ma Lijiang, Hanna Amy E, Thilaganathan Nishan, Moghaddam Seyed, Evans Christopher M, Li Huaiguang, Cai Wei-Wen, Sato Mitsuo, Minna John D, Wu Hong, Creighton Chad J, Demayo Francesco J, Wistuba Ignacio I, Kurie Jonathan M
Abstract excerpt
Phosphatase and tensin homologue deleted from chromosome 10 (Pten) is expressed aberrantly in non-small cell lung cancer cells, but the role of Pten in lung neoplasia has not been fully elucidated. In this study, we used a genetic approach to inactivate Pten in the bronchial epithelium of mice. Although, by itself, Pten inactivation had no discernible effect on bronchial epithelial histology, it accelerated lung...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.