Article
Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer.
Cancer prevention research (Philadelphia, Pa.) - 1 Nov 2011
Maier Colleen R, Hollander M Christine, Hobbs Evthokia A, Dogan Irem, Linnoila R Ilona, Dennis Phillip A
Abstract excerpt
Smoking is the leading cause of preventable cancer deaths in the United States. Nicotine replacement therapies (NRT) have been developed to aid in smoking cessation, which decreases lung cancer incidence. However, the safety of NRT is controversial because numerous preclinical studies have shown that nicotine enhances tumor cell growth in vitro and in vivo. We modeled NRT in mice to determine the effects of...
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