Article
Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen.
Critical reviews in toxicology - 1 Jan 1996
Hecht S S
Abstract excerpt
This article reviews recent advances in the biochemistry and molecular biology of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific pulmonary carcinogen believed to be involved in the induction of lung cancer in smokers. Several aspects of NNK bioactivation are addressed, including identification of its metabolites in laboratory animals and humans, cytochrome P450 enzyme involvement in its...
Topics
- Animals
- Animals, Laboratory
- Carcinogens
- Cell Transformation, Neoplastic
- Cytochrome P-450 Enzyme System
- DNA Adducts
- Genes, p53
- Genes, ras
- Humans
- Lung Neoplasms
- Mice
- Mutation
- Nitrosamines
- Oncogenes
- Plants, Toxic
- Protein Binding
- Proto-Oncogene Proteins p21(ras)
- Proto-Oncogenes