Article
Ki-ras mutations in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-initiated and butylated hydroxytoluene-promoted lung tumors in A/J mice.
Molecular carcinogenesis - 1 Sept 1994
Matzinger S A, Gunning W T, You M, Castonguay A
Abstract excerpt
The promotional effects of butylated hydroxytoluene (BHT) on lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) was evaluated in a two-stage model of lung tumorigenesis in the A/J mouse. Mice were treated in two separate experiments with 1.54 mmol/kg (9.1 mg/mouse) NNK, which induced an average of 8.4 and 9.1 tumors/mouse in the experiments. Animals fed a diet that contained 1 g/kg...
Topics
- Adenoma
- Animals
- Base Sequence
- Butylated Hydroxytoluene
- Carcinogens
- Female
- Genes, ras
- Lung Neoplasms
- Mice
- Mice, Inbred A
- Molecular Sequence Data