Article
Ki-ras mutation and cell proliferation of lung lesions induced by 1-nitropyrene in A/J mice.
Molecular carcinogenesis - 1 Aug 1998
Bai F, Nakanishi Y, Takayama K, Pei X H, Tokiwa H, Hara N
Abstract excerpt
In this study, lung lesions were found in male A/J mice 24 wk after intraperitoneal injection of 1-nitropyrene (1-NP). The lesions were classified into three categories: alveolar/bronchiolar hyperplasia, adenoma, and adenocarcinoma. The proliferation kinetics of cells in the lesions were evaluate...
Topics
- Adenoma
- Animals
- Cell Division
- Genes, ras
- Lung Neoplasms
- Male
- Mice
- Mice, Inbred A
- Mutagens
- Mutation
- Nucleolus Organizer Region
- Proliferating Cell Nuclear Antigen
- Pyrenes
- Silver Staining