Article
eSGA: E. coli synthetic genetic array analysis.
Nature methods - 1 Sept 2008
Butland Gareth, Babu Mohan, Díaz-Mejía J Javier, Bohdana Fedyshyn, Phanse Sadhna, Gold Barbara, Yang Wenhong, Li Joyce, Gagarinova Alla G, Pogoutse Oxana, Mori Hirotada, Wanner Barry L, Lo Henry, Wasniewski Jas, Christopolous Constantine, Ali Mehrab, Venn Pascal, Safavi-Naini Anahita, Sourour Natalie, Caron Simone, Choi Ja-Yeon, Laigle Ludovic, Nazarians-Armavil Anaies, Deshpande Avnish, Joe Sarah, Datsenko Kirill A, Yamamoto Natsuko, Andrews Brenda J, Boone Charles, Ding Huiming, Sheikh Bilal, Moreno-Hagelseib Gabriel, Greenblatt Jack F, Emili Andrew
Abstract excerpt
Physical and functional interactions define the molecular organization of the cell. Genetic interactions, or epistasis, tend to occur between gene products involved in parallel pathways or interlinked biological processes. High-throughput experimental systems to examine genetic interactions on a genome-wide scale have been devised for Saccharomyces cerevisiae, Schizosaccharomyces pombe, Caenorhabditis elegans and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.