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Article

Systematic mapping of genetic interaction networks.

Annual review of genetics - 1 Jan 2009

Dixon Scott J, Costanzo Michael, Baryshnikova Anastasia, Andrews Brenda, Boone Charles

Abstract excerpt

Genetic interactions influencing a phenotype of interest can be identified systematically using libraries of genetic tools that perturb biological systems in a defined manner. Systematic screens conducted in the yeast Saccharomyces cerevisiae have identified thousands of genetic interactions and provided insight into the global structure of biological networks. Techniques enabling systematic genetic interaction...

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Identifiers

PMID: 19712041
DOI: 10.1146/annurev.genet.39.073003.114751

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