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Article

dSLAM analysis of genome-wide genetic interactions in Saccharomyces cerevisiae.

Methods (San Diego, Calif.) - 1 Feb 2007

Pan Xuewen, Yuan Daniel S, Ooi Siew-Loon, Wang Xiaoling, Sookhai-Mahadeo Sharon, Meluh Pamela, Boeke Jef D

Abstract excerpt

Analysis of genetic interactions has been extensively exploited to study gene functions and to dissect pathway structures. One such genetic interaction is synthetic lethality, in which the combination of two non-lethal mutations leads to loss of organism viability. We have developed a dSLAM (heterozygote diploid-based synthetic lethality analysis with microarrays) technology that effectively studies synthetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17189863
DOI: 10.1016/j.ymeth.2006.07.033
PMCID: PMC2491713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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