Article
Synthetic Genetic Array Analysis.
Cold Spring Harbor protocols - 1 Apr 2016
Kuzmin Elena, Costanzo Michael, Andrews Brenda, Boone Charles
Abstract excerpt
Genetic interaction studies have been used to characterize unknown genes, assign membership in pathway and complex, and build a comprehensive functional map of a eukaryotic cell. Synthetic genetic array (SGA) methodology automates yeast genetic analysis and enables systematic mapping of genetic interactions. In its simplest form, SGA consists of a series of replica pinning steps that enable construction of...
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