Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping Synthetic Dosage Lethal Genetic Interactions in Saccharomyces cerevisiae.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021

Hamza Akil, Amitzi Leanne, Duffy Supipi, Hieter Philip

Abstract excerpt

Synthetic dosage lethality (SDL) is a type of genetic interaction that occurs when increasing the expression of a gene causes a fitness defect, such as lethality, in a specific mutant background but has little effect on fitness in a wild-type background. SDL genetic interactions discovered in model organisms such as the budding yeast, Saccharomyces cerevisiae , represent candidate genetic interactions that may be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Lethal
Share to Mutation
Share to Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Saccharomyces cerevisiae

Share to Synthetic Lethal Mutations

Source

Identifiers

PMID: 34590269
DOI: 10.1007/978-1-0716-1740-3_2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping Synthetic Dosage Lethal Genetic Interactions in Saccharomyces cerevisiae.PMID 34590269Read ↗

Synthetic genetic array analysis for global mapping of genetic networks in yeast.Semantic proximity Read ↗

dSLAM analysis of genome-wide genetic interactions in Saccharomyces cerevisiae.Semantic proximity Read ↗

Functional Analysis of Kinases and Transcription Factors in Saccharomyces cerevisiae Using an Integrated Overexpression Library.Semantic proximity Read ↗

Synthetic genetic array analysis in Saccharomyces cerevisiae.Semantic proximity Read ↗

SGAM: an array-based approach for high-resolution genetic mapping in Saccharomyces cerevisiae.Semantic proximity Read ↗

Phenotypic activation to discover biological pathways and kinase substrates.Semantic proximity Read ↗

Synthetic Genetic Array Analysis.Semantic proximity Read ↗

Sentinel interaction mapping - a generic approach for the functional analysis of human disease gene variants using yeast.Semantic proximity Read ↗

Sentinel Interaction Mapping (SIM) – A generic approach for the functional analysis of human disease gene variants using yeastSemantic proximity Read ↗

Analysis of genetic interactions on a genome-wide scale in budding yeast: diploid-based synthetic lethality analysis by microarray.Semantic proximity Read ↗

Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs.Semantic proximity Read ↗

Trigenic Synthetic Genetic Array (τ-SGA) Technique for Complex Interaction Analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.