Article
Quantitative genome-wide genetic interaction screens reveal global epistatic relationships of protein complexes in Escherichia coli.
PLoS genetics - 1 Feb 2014
Babu Mohan, Arnold Roland, Bundalovic-Torma Cedoljub, Gagarinova Alla, Wong Keith S, Kumar Ashwani, Stewart Geordie, Samanfar Bahram, Aoki Hiroyuki, Wagih Omar, Vlasblom James, Phanse Sadhna, Lad Krunal, Yeou Hsiung Yu Angela, Graham Christopher, Jin Ke, Brown Eric, Golshani Ashkan, Kim Philip, Moreno-Hagelsieb Gabriel, Greenblatt Jack, Houry Walid A, Parkinson John, Emili Andrew
Abstract excerpt
Large-scale proteomic analyses in Escherichia coli have documented the composition and physical relationships of multiprotein complexes, but not their functional organization into biological pathways and processes. Conversely, genetic interaction (GI) screens can provide insights into the biologi...
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