Article
PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans.
Molecular cell - 11 Jul 2008
Batista Pedro J, Ruby J Graham, Claycomb Julie M, Chiang Rosaria, Fahlgren Noah, Kasschau Kristin D, Chaves Daniel A, Gu Weifeng, Vasale Jessica J, Duan Shenghua, Conte Darryl, Luo Shujun, Schroth Gary P, Carrington James C, Bartel David P, Mello Craig C
Abstract excerpt
In metazoans, Piwi-related Argonaute proteins have been linked to germline maintenance, and to a class of germline-enriched small RNAs termed piRNAs. Here we show that an abundant class of 21 nucleotide small RNAs (21U-RNAs) are expressed in the C. elegans germline, interact with the C. elegans Piwi family member PRG-1, and depend on PRG-1 activity for their accumulation. The PRG-1 protein is expressed throughout...
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