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Article

Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines.

Genes & development - 1 Nov 2012

Ishizu Hirotsugu, Siomi Haruhiko, Siomi Mikiko C

Abstract excerpt

PIWI-interacting RNAs (piRNAs) are endogenous small noncoding RNAs that act as guardians of the genome, protecting it from invasive transposable elements in the germline. Animals lacking piRNA functions show defects in gametogenesis and exhibit sterility. Their descendants are also predisposed to inheriting mutations. Thus, the piRNA pathway has evolved to repress transposons post-transcriptionally and/or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23124062
DOI: 10.1101/gad.203786.112
PMCID: PMC3489994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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