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Article

Differential impact of the HEN1 homolog HENN-1 on 21U and 26G RNAs in the germline of Caenorhabditis elegans.

PLoS genetics - 1 Jan 2012

Kamminga Leonie M, van Wolfswinkel Josien C, Luteijn Maartje J, Kaaij Lucas J T, Bagijn Marloes P, Sapetschnig Alexandra, Miska Eric A, Berezikov Eugene, Ketting René F

Abstract excerpt

RNA interference (RNAi)-related pathways affect gene activity by sequence-specific recruitment of Ago proteins to mRNA target molecules. The sequence specificity of this process stems from small RNA (sRNA) co-factors bound by the Ago protein. Stability of sRNA molecules in some pathways is in part regulated by Hen1-mediated methylation of their 3' ends. Here we describe the effects of the Caenorhabditis elegans...

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Identifiers

PMID: 22829772
DOI: 10.1371/journal.pgen.1002702
PMCID: PMC3400576

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Source receipt: pubmed, retrieved 7 Sept 2026.

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