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Article

RG motifs promote piRNA-mediated gene silencing in C. elegans.

Nucleic acids research - 26 Nov 2025

Wallis Dylan C, Phillips Carolyn M

Abstract excerpt

Argonaute proteins are essential components of RNA silencing pathways, and their N-terminal extensions, particularly in the PIWI clade, often harbor conserved RG motifs. Despite their prevalence, the function of these motifs remains poorly understood. In this study, we investigate the RG motifs in the N-terminal region of Caenorhabditis elegans PRG-1, a PIWI clade Argonaute. Sequence alignment across...

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Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
RNA, Small Interfering
Argonaute Proteins
Amino Acid Motifs
Gene Silencing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

RNA Interference

Mutation

Methylation

Piwi-Interacting RNA

Source

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Identifiers

PMID: 41414669
DOI: 10.1093/nar/gkaf1331
PMCID: PMC12714567

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