Systematic identification of germ granule proteins reveals specialized roles in RNAi and small RNA inheritance.

doi:10.1101/gad.353482.125

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Article

Systematic identification of germ granule proteins reveals specialized roles in RNAi and small RNA inheritance.

Genes & development - 26 Aug 2026

Chen Shihui, Prescott Lucas H, Mello Craig C, Phillips Carolyn M

Abstract excerpt

Biomolecular condensates, such as germ granules, organize RNAi pathways critical for fertility and genome regulation. However, the protein composition and functional contributions of these condensates remain poorly defined. Here, we applied TurboID proximity labeling to the Caenorhabditis elegans germ granule protein SIMR-1, integrating mass spectrometry with genetic screening, CRISPR-based tagging, and small RNA...

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PMID: 42538287
DOI: 10.1101/gad.353482.125

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