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Article

A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans.

Developmental cell - 26 Mar 2018

Tang Wen, Seth Meetu, Tu Shikui, Shen En-Zhi, Li Qian, Shirayama Masaki, Weng Zhiping, Mello Craig C

Abstract excerpt

In metazoans, Piwi-related Argonaute proteins engage piRNAs (Piwi-interacting small RNAs) to defend the genome against invasive nucleic acids, such as transposable elements. Yet many organisms-including worms and humans-express thousands of piRNAs that do not target transposons, suggesting that piRNA function extends beyond genome defense. Here, we show that the X chromosome-derived piRNA 21ux-1 downregulates...

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Identifiers

PMID: 29456136
DOI: 10.1016/j.devcel.2018.01.025
PMCID: PMC5991626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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