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Article

PRDE-1 is a nuclear factor essential for the biogenesis of Ruby motif-dependent piRNAs in C. elegans.

Genes & development - 1 Apr 2014

Weick Eva-Maria, Sarkies Peter, Silva Nicola, Chen Ron A, Moss Sylviane M M, Cording Amy C, Ahringer Julie, Martinez-Perez Enrique, Miska Eric A

Abstract excerpt

Piwi-interacting RNAs (piRNA) are small regulatory RNAs with essential roles in maintaining genome integrity in animals and protists. Most Caenorhabditis elegans piRNAs are transcribed from two genomic clusters that likely contain thousands of individual transcription units; however, their biogen...

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Identifiers

PMID: 24696457
DOI: 10.1101/gad.238105.114
PMCID: PMC4015492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24696457-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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PRDE-1 is a nuclear factor essential for the biogenesis of Ruby motif-dependent piRNAs in C. elegans.PMID 24696457Read ↗

Function, targets, and evolution of Caenorhabditis elegans piRNAs.Semantic proximity Read ↗

PID-1 is a novel factor that operates during 21U-RNA biogenesis in Caenorhabditis elegans.Semantic proximity Read ↗

The USTC complex co-opts an ancient machinery to drive piRNA transcription in <i>C. elegans</i>Semantic proximity Read ↗

The RNase PARN-1 Trims piRNA 3' Ends to Promote Transcriptome Surveillance in C. elegans.Semantic proximity Read ↗

RG motifs promote piRNA-mediated gene silencing in <i>C. elegans</i>Semantic proximity Read ↗

The RNA Polymerase II core subunit RPB-9 directs transcriptional elongation at piRNA loci in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Epigenetic inheritance and evolution in nematodesSemantic proximity Read ↗

The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in <i>C. elegans</i>Semantic proximity Read ↗

The Upstream Sequence Transcription Complex Dictates Nucleosome Positioning and Promoter Accessibility at piRNA Genes in the <i>C. elegans</i> Germ LineSemantic proximity Read ↗

The IDR-containing protein PID-2 affects Z granules and is required for piRNA-induced silencing in the embryoSemantic proximity Read ↗

Biogenesis of mature piRNAs in <i>Caenorhabditis elegans</i> is dependent on orchestration between multiple ribonucleases and PRG-1Semantic proximity Read ↗

PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans.Semantic proximity Read ↗

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