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Article

Small-RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants.

Nature cell biology - 1 Feb 2020

Barucci Giorgia, Cornes Eric, Singh Meetali, Li Blaise, Ugolini Martino, Samolygo Aleksei, Didier Celine, Dingli Florent, Loew Damarys, Quarato Piergiuseppe, Cecere Germano

Abstract excerpt

PIWI-interacting RNAs (piRNAs) promote fertility in many animals. However, whether this is due to their conserved role in repressing repetitive elements (REs) remains unclear. Here, we show that the progressive loss of fertility in Caenorhabditis elegans lacking piRNAs is not caused by derepression of REs or other piRNA targets but, rather, is mediated by epigenetic silencing of all of the replicative histone...

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Identifiers

PMID: 32015436
DOI: 10.1038/s41556-020-0462-7
PMCID: PMC7272227

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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