Article

The IDR-containing protein PID-2 affects Z granules and is required for piRNA-induced silencing in the embryo

2020-04-14

Abstract excerpt

In Caenorhabditis elegans , the piRNA (21U RNA) pathway is required to establish proper gene regulation and an immortal germline. To achieve this, PRG-1-bound 21U RNAs trigger silencing mechanisms mediated by RNA-dependent RNA polymerase (RdRP)-synthetized 22G RNAs. This silencing can become PRG-1-independent, and heritable over many generations. This state is named RNAe. It is unknown how and when RNAe is establ...

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Literature Corpus work: 7436b1e2-41eb-5a80-9cb0-b0fd665ecb45
DOI: 10.1101/2020.04.14.040584

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