Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7.

Article

Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7.

Cancer research - 1 Aug 1991

Buchmann A, Ruggeri B, Klein-Szanto A J, Balmain A

Abstract excerpt

Analysis of benign and malignant mouse skin tumors had previously shown that amplification of a mutant H-ras allele or loss of the normal allele was generally seen only in high grade or spindle cell tumors. The normal:mutant ras gene dosage has been studied directly by polymerase chain reaction a...

Topics

Alleles
Animals
Carcinoma
Carcinoma, Squamous Cell
Chemotaxis
Genes, ras
Mice
Mutation
Neoplasm Invasiveness
Polymerase Chain Reaction
Skin Neoplasms
Tumor Cells, Cultured

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