Article
Genetic changes during mouse skin tumorigenesis.
Environmental health perspectives - 1 Jun 1991
Burns P A, Bremner R, Balmain A
Abstract excerpt
This paper describes specific genetic changes involving chromosome 7 in mouse skin tumors, the most important consequence of which appears to be an alteration in the allelic balance of normal and mutant H-ras genes. The use of restriction-fragment-length polymorphisms in F1 hybrid mice demonstrat...
Topics
- Alleles
- Animals
- Carcinoma
- Chromosomes
- DNA Damage
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Genes, ras
- Hybridization, Genetic
- Methylnitronitrosoguanidine
- Mice
- Papilloma
- Polymorphism, Restriction Fragment Length
- Proto-Oncogene Proteins p21(ras)
- Recombination, Genetic
- Skin Neoplasms
- Trisomy