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Article

Chromosomal instability and phenotypic plasticity during the squamous-spindle carcinoma transition: association of a specific T(14;15) with malignant progression.

Oncogene - 17 Nov 2005

Pons Mar, Cigudosa Juan C, Rodríguez-Perales Sandra, Bella José L, González Cristina, Gamallo Carlos, Quintanilla Miguel

Abstract excerpt

In mouse epidermal carcinogenesis, the latest stage of malignant progression involves the transition from squamous cell carcinoma to a highly aggressive type of tumor with spindle morphology. In this work, we have isolated a minor epithelial cell subpopulation (CarC-R) contained in the highly malignant spindle carcinoma cell line CarC. CarC-R exhibited a drastic reduction in tumorigenicity when compared with...

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Source

Identifiers

PMID: 16007119
DOI: 10.1038/sj.onc.1208903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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