Article
Chromosomal instability and phenotypic plasticity during the squamous-spindle carcinoma transition: association of a specific T(14;15) with malignant progression.
Oncogene - 17 Nov 2005
Pons Mar, Cigudosa Juan C, Rodríguez-Perales Sandra, Bella José L, González Cristina, Gamallo Carlos, Quintanilla Miguel
Abstract excerpt
In mouse epidermal carcinogenesis, the latest stage of malignant progression involves the transition from squamous cell carcinoma to a highly aggressive type of tumor with spindle morphology. In this work, we have isolated a minor epithelial cell subpopulation (CarC-R) contained in the highly malignant spindle carcinoma cell line CarC. CarC-R exhibited a drastic reduction in tumorigenicity when compared with...
Topics
- Animals
- Carcinoma, Squamous Cell
- Cell Line, Tumor
- Cell Transformation, Neoplastic
- Chromosomal Instability
- Cyclin-Dependent Kinase Inhibitor p16
- Disease Models, Animal
- Disease Progression
- Epithelial Cells
- Fibroblasts
- Karyotyping
- Mice