Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

E6 and E7 oncoproteins induce distinct patterns of chromosomal aneuploidy in skin tumors from transgenic mice.

Cancer research - 15 Jan 2004

Schaeffer Anthony J, Nguyen Marie, Liem Amy, Lee Denis, Montagna Cristina, Lambert Paul F, Ried Thomas, Difilippantonio Michael J

Abstract excerpt

Inactivation of the tumor suppressor genes p53 and Rb are two of the most common genetic alterations in cancer cells. We use a mouse model to dissect the consequences of compromising the function of either of these genes on the maintenance of genomic stability. Thirteen cell lines established from skin tumors of mice expressing either the E6 or E7 oncoprotein of the human papillomavirus (HPV) type 16 under...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 9,10-Dimethyl-1,2-benzanthracene
Share to Aneuploidy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinogens

Share to Chromosomes

Share to Genes, Retinoblastoma

Share to Oncogene Proteins, Viral

Share to Papillomavirus E7 Proteins

Share to Tetradecanoylphorbol Acetate

Source

Identifiers

PMID: 14744767
DOI: 10.1158/0008-5472.can-03-0124

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

E6 and E7 oncoproteins induce distinct patterns of chromosomal aneuploidy in skin tumors from transgenic mice.PMID 14744767Read ↗

Tumorigenicity by human papillomavirus type 16 E6 and E7 in transgenic mice correlates with alterations in epithelial cell growth and differentiationSemantic proximity Read ↗

Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogeneSemantic proximity Read ↗

The Human Papillomavirus E6 Oncogene Dysregulates the Cell Cycle and Contributes to Cervical Carcinogenesis through Two Independent ActivitiesSemantic proximity Read ↗

Epidermal cancer associated with expression of human papillomavirus type 16 E6 and E7 oncogenes in the skin of transgenic mice.Semantic proximity Read ↗

Critical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesis.Semantic proximity Read ↗

Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo.Semantic proximity Read ↗

HPV-18 E6 mutants reveal p53 modulation of viral DNA amplification in organotypic cultures.Semantic proximity Read ↗

Human Papillomavirus Oncoproteins E6 and E7 Independently Abrogate the Mitotic Spindle CheckpointSemantic proximity Read ↗

HPV16 E6 confers p53-dependent and p53-independent phenotypes in the epidermis of mice deficient for E6AP.Semantic proximity Read ↗

Role of Rb-dependent and Rb-independent functions of papillomavirus E7 oncogene in head and neck cancer.Semantic proximity Read ↗

Examination of the pRb-Dependent and pRb-Independent Functions of E7 In VivoSemantic proximity Read ↗

Human papillomavirus types 16 E6 and E7 contribute differently to carcinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.