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Article

Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7.

Cell - 4 May 1990

Bremner R, Balmain A

Abstract excerpt

Initiation of tumorigenesis in mouse skin can be accomplished by mutagenesis of the H-ras gene by treatment with chemical carcinogens. A mouse model system has been developed to study the additional genetic events that take place during tumor progression. Skin carcinomas were induced in F1 hybrid...

Topics

Alleles
Animals
Cell Line
Chromosome Mapping
Crosses, Genetic
DNA, Neoplasm
Female
Gene Amplification
Genes, ras
Heterozygote
Homozygote
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred Strains

Mutation

Oligonucleotide Probes

Skin Neoplasms

Source

Identifiers

PMID: 2185890
DOI: 10.1016/0092-8674(90)90523-h

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2185890-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7.PMID 2185890Read ↗

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