Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional loss of tumour suppressor genes in multistage chemical carcinogenesis.

Princess Takamatsu symposia - 1 Jan 1991

Balmain A, Kemp C J, Burns P A, Stoler A B, Fowlis D J, Akhurst R J

Abstract excerpt

Studies of multistage carcinogenesis in mouse skin have provided many of the early concepts of tumour initiation, promotion and progression. Genetic approaches have led to the identification of a number of mutational alterations in proto-oncogenes and tumour suppressor genes which take place at specific stages of carcinogenesis in this particular system. Initiation involves, at least in a proportion of tumours,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to Carcinoma, Squamous Cell
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, ras

Share to Genes, Tumor Suppressor

Share to Mutation

Share to Skin Neoplasms

Source

Identifiers

PMID: 1844254

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional loss of tumour suppressor genes in multistage chemical carcinogenesis.PMID 1844254Read ↗

Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7.Semantic proximity Read ↗

Genetic changes during mouse skin tumorigenesis.Semantic proximity Read ↗

Overlapping loss of heterozygosity by mitotic recombination on mouse chromosome 7F1-ter in skin carcinogenesis.Semantic proximity Read ↗

Molecular mechanisms of invasion and metastasis during mouse skin tumour progression.Semantic proximity Read ↗

Analysing p53 tumour suppressor functions in mice.Semantic proximity Read ↗

An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations.Semantic proximity Read ↗

Transgenic mice and squamous multistage skin carcinogenesis.Semantic proximity Read ↗

Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7.Semantic proximity Read ↗

New approaches for modelling cancer mechanisms in the mouseSemantic proximity Read ↗

Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage.Semantic proximity Read ↗

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.Semantic proximity Read ↗

Nonrandom duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.