Article
Molecular mechanisms of invasion and metastasis during mouse skin tumour progression.
Invasion & metastasis - 1 Jan 2000
Portella G, Liddell J, Crombie R, Haddow S, Clarke M, Stoler A B, Balmain A
Abstract excerpt
The ultimate stage of carcinogenesis in both human and mouse epithelial cells is the ability to invade surrounding tissues and metastasize to distant sites. In mouse skin tumours, the development of the invasive, spindle cell phenotype is associated with an imbalance of alleles on mouse chromosom...
Topics
- Animals
- Carcinoma
- Disease Progression
- Mice
- Neoplasm Invasiveness
- Phenotype
- Skin Neoplasms
- Tumor Cells, Cultured