Article
Allelotype analysis of mouse skin tumors using polymorphic microsatellites: sequential genetic alterations on chromosomes 6, 7, and 11.
Cancer research - 15 Dec 1993
Kemp C J, Fee F, Balmain A
Abstract excerpt
Allelotype analysis of human tumors has been instrumental in the effort to discover and clone novel tumor suppressor genes. However, this approach has not been systematically applied to animal models of carcinogenesis. We describe here the first attempt to allelotype a nonhuman tumor, i.e., chemi...
Topics
- Alleles
- Animals
- Carcinoma
- Chromosome Aberrations
- Chromosome Deletion
- Genes, p53
- Genetic Markers
- Humans
- Mice
- Mice, Inbred BALB C
- Papilloma
- Polymorphism, Restriction Fragment Length
- Proto-Oncogenes
- Skin Neoplasms
- Trisomy
