Article
The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event.
The Journal of cell biology - 1 Sept 1993
Stoler A B, Stenback F, Balmain A
Abstract excerpt
Squamous carcinomas of both human and rodent origin can undergo a transition to a more invasive, metastatic phenotype involving reorganization of the cytoskeleton, loss of cell adhesion molecules such as E-cadherin and acquisition of a fibroblastoid or spindle cell morphology. We have developed a series of cell lines from mouse skin tumors which represent different stages of carcinogenesis, including benign...
Topics
- Animals
- Antigens, Differentiation
- Cadherins
- Carcinoma
- Carcinoma, Squamous Cell
- Cell Transformation, Neoplastic
- Cytoskeletal Proteins
- Cytoskeleton
- Desmoplakins
- Epidermis
- Fluorescent Antibody Technique