Article
Nonrandom duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumors.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1990
Bianchi A B, Aldaz C M, Conti C J
Abstract excerpt
We analyzed the normal/mutated allelic ratio of the Ha-ras-1 gene in mouse skin squamous cell carcinomas induced by initiation with dimethylbenz[a]anthracene and promotion with phorbol 12-myristate 13-acetate. DNA for these studies was obtained from short-term tumor cultures (24-72 hr) to elimina...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Alleles
- Animals
- Carcinoma, Squamous Cell
- Cell Differentiation
- Cell Transformation, Neoplastic
- Chromosome Mapping
- Gene Amplification
- Genes, ras
- Immunoenzyme Techniques
- Keratins
- Mice
- Mice, Inbred Strains
- Models, Genetic
- Mutation
- Nucleic Acid Hybridization
- Polymorphism, Restriction Fragment Length
- Skin Neoplasms