Induction of different genetic changes by different classes of chemical carcinogens during progression of mouse skin tumors.

doi:10.1002/mc.2940110206

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Article

Induction of different genetic changes by different classes of chemical carcinogens during progression of mouse skin tumors.

Molecular carcinogenesis - 1 Oct 1994

Bremner R, Kemp C J, Balmain A

Abstract excerpt

By analysis of skin tumors from F1 hybrid mice we demonstrated that the genetic events that occur during tumor progression depend on the type of chemical carcinogenesis protocol used to induce tumor growth. More than 95% of tumors induced by initiation with 7,12-dimethylbenz[a]anthracene (DMBA) a...

Topics

9,10-Dimethyl-1,2-benzanthracene
Animals
Chromosome Aberrations
Chromosome Deletion
Genes, ras
Methylnitronitrosoguanidine
Mice
Mutation
Polymorphism, Restriction Fragment Length
Skin Neoplasms
Tetradecanoylphorbol Acetate
Trisomy

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