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Article

Pathway based analysis of SNPs with relevance to 5-FU therapy: relation to intratumoral mRNA expression and survival.

International journal of cancer - 1 Aug 2008

Nordgard Silje H, Alnaes Grethe I G, Hihn Björn, Lingjaerde Ole Christian, Liestøl Knut, Tsalenko Anya, Sørlie Therese, Lønning Per Eystein, Børresen-Dale Anne-Lise, Kristensen Vessela N

Abstract excerpt

Genetic factors are thought to play a role in resistance towards chemotherapeutic agents such as 5-fluorouracil (5-FU). Approximately 30 genes are directly or indirectly involved in 5-FU metabolism, and genetic variation in any of these may contribute to anti-tumor response. Polymorphisms in these genes were analyzed in relation to tumoral mRNA levels of 5-FU metabolizing genes, response to chemotherapy and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18498133
DOI: 10.1002/ijc.23541

Genes

TYMS
DHFR
MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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