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Article

Thymidylate synthase gene polymorphisms effecting 5-FU response in breast cancer patients.

Cancer biomarkers : section A of Disease markers - 1 Jan 2010

Kumar Kalyana, Vamsy Mohana, Jamil Kaiser

Abstract excerpt

Our study supports the Drug-Gene Interaction principle, where patients experience adverse drug reactions (ADRs) due to genetic predisposition or due to single nucleotide polymorphisms (SNPs) in drug metabolizing genes. The target enzyme for 5- Fluorouracil is thymidylate synthase (TYMS) this enzyme is also involved in folate metabolism. We determined the frequencies of polymorphisms in drug metabolizing enzyme...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20571234
DOI: 10.3233/CBM-2009-0121
PMCID: PMC12922847

Genes

TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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