Combinations of polymorphisms in genes involved in the 5-Fluorouracil metabolism pathway are associated with gastrointestinal toxicity in chemotherapy-treated colorectal cancer patients.

doi:10.1158/1078-0432.CCR-11-0304

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Article

Combinations of polymorphisms in genes involved in the 5-Fluorouracil metabolism pathway are associated with gastrointestinal toxicity in chemotherapy-treated colorectal cancer patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2011

Afzal Shoaib, Gusella Milena, Vainer Ben, Vogel Ulla B, Andersen Jon T, Broedbaek Kasper, Petersen Morten, Jimenez-Solem Espen, Bertolaso Laura, Barile Carmen, Padrini Roberto, Pasini Felice, Jensen Søren A, Poulsen Henrik E

Abstract excerpt

PURPOSE: The purpose of this study was to investigate whether specific combinations of polymorphisms in genes encoding proteins involved in 5-fluorouracil (5-FU) pharmacokinetics and pharmacodynamics are associated with increased risk of treatment-induced toxicity. EXPERIMENTAL DESIGN: We analyzed two cohorts of 161 and 340 patients, the exploration and validation cohort, respectively. All patients were treated...

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PMID: 21471424
DOI: 10.1158/1078-0432.CCR-11-0304

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MTHFR
TYMS

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