Article
Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influence.
Cancer research - 1 Feb 2009
Brody Jonathan R, Hucl Tomas, Costantino Christina L, Eshleman James R, Gallmeier Eike, Zhu Heng, van der Heijden Michiel S, Winter Jordan M, Wikiewicz Agnieszka K, Yeo Charles J, Kern Scott E
Abstract excerpt
The major determinants of 5-flurouracil (5-FU) response would seem, based on accumulated literature, to be thymidylate synthase (TYMS, TS) expression levels, TS gene modifications, and TP53 status. We tested 5-FU sensitivity in yeast and human cancer cell models in which TS or TP53 alleles and expression were varied. Polymorphic TS tandem repeat status, TS expression levels reported, TS intragenic mutations, and...
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