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Article

Involvement of target gene polymorphisms in 5-Fluorouracil toxicity: a case report.

Pharmacology - 1 Jan 2012

Scalvini Anna, Ferrari Vittorio, Bodei Serena, Arcangeli Giuseppina, Consoli Francesca, Spano PierFranco, Sigala Sandra

Abstract excerpt

Personalized medicine is becoming an important tool in oncology, both in preventing disease and in optimizing the treatment of existing cancers. Here we describe the cases of 2 patients with relevant systemic toxicity following 5-fluorouracil (5-FU) therapy and we study the more frequent polymorphisms in the target genes, in particular: (1) the variability in the number of 28-base repetitions present in the...

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Share to Dihydrouracil Dehydrogenase (NADP)
Share to Fluorouracil

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Single Nucleotide

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PMID: 22343422
DOI: 10.1159/000335784

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