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Article

Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2004

Lecomte Thierry, Ferraz Jean-Marc, Zinzindohoué Franck, Loriot Marie-Anne, Tregouet David-Alexandre, Landi Bruno, Berger Anne, Cugnenc Paul-Henri, Jian Raymond, Beaune Philippe, Laurent-Puig Pierre

Abstract excerpt

PURPOSE: The target enzyme for 5-fluorouracil (5-FU) is thymidylate synthase (TS). The TYMS gene encoding this enzyme is polymorphic, having either double (2R) or tri-tandem (3R) repeats of a 28-bp sequence in the promoter region and a 6-bp variation in the 3'-untranslated region (3'-UTR). TS expression predicts response to 5-FU-based chemotherapy, and the expression seems to be determined by the TYMS gene...

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Identifiers

PMID: 15355920
DOI: 10.1158/1078-0432.CCR-04-0169

Genes

TYMS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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