Article
The association of polymorphisms in 5-fluorouracil metabolism genes with outcome in adjuvant treatment of colorectal cancer.
Pharmacogenomics - 1 Sept 2011
Afzal Shoaib, Gusella Milena, Jensen Søren Astrup, Vainer Ben, Vogel Ulla, Andersen Jon Trærup, Brødbæk Kasper, Petersen Morten, Jimenez-Solem Espen, Adleff Vilmos, Budai Barna, Hitre Erika, Láng István, Orosz Eniko, Bertolaso Laura, Barile Carmen, Padrini Roberto, Kralovánszky Judit, Pasini Felice, Poulsen Henrik Enghusen
Abstract excerpt
AIM: The purpose of this study was to investigate whether specific combinations of polymorphisms in 5-fluorouracil (5-FU) metabolism-related genes were associated with outcome in 5-FU-based adjuvant treatment of colorectal cancer. METHODS: We analyzed two cohorts of 302 and 290 patients, respectively, one cohort for exploratory analyses and another cohort for validating the exploratory analyses. A total of ten...
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