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Article

<i>Thymidylate synthase</i>gene variations: predictive and prognostic markers

22 Apr 2009

Abstract excerpt

Since its introduction more than 50 years ago by Heidelberger et al., the fluoropyrimidine 5-fluorouracil (5-FU) has remained the mainstay of therapeutic regimens used in the treatment of colorectal cancer and other human malignancies, with single-agent response rates of 20% to 25% in advanced disease stage. Pharmacogenomics has emerged as a useful tool to address interindividual gene variations by analyzing the...

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PMID: 19383851
DOI: 10.1158/1535-7163.mct-08-0219

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