Pharmacogenetic Analysis of the UK MRC (Medical Research Council) MAGIC Trial: Association of Polymorphisms with Toxicity and Survival in Patients Treated with Perioperative Epirubicin, Cisplatin, and 5-fluorouracil (ECF) Chemotherapy.

doi:10.1158/1078-0432.CCR-16-3142

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Pharmacogenetic Analysis of the UK MRC (Medical Research Council) MAGIC Trial: Association of Polymorphisms with Toxicity and Survival in Patients Treated with Perioperative Epirubicin, Cisplatin, and 5-fluorouracil (ECF) Chemotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2017

Smyth Elizabeth, Zhang Shenli, Cunningham David, Wotherspoon Andrew, Soong Richie, Peckitt Clare, Valeri Nicola, Fassan Matteo, Rugge Massimo, Okines Alicia, Allum William, Stenning Sally, Nankivell Matthew, Langley Ruth, Tan Patrick

Abstract excerpt

Purpose: Germline polymorphisms may affect chemotherapy efficacy and toxicity. We examined the effect of polymorphisms in drug metabolism and DNA repair genes on pathologic response rates, survival, and toxicity for patients randomized to surgery alone or perioperative ECF chemotherapy in the MRC MAGIC trial.Experimental Design: DNA was extracted from nontumor resection formalin-fixed paraffin-embedded (FFPE)...

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Identifiers

PMID: 28972045
DOI: 10.1158/1078-0432.CCR-16-3142
PMCID: PMC6175041

Genes

GSTT1
ERCC1
ERCC2
GSTP1
TYMS
XRCC1

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Pharmacogenetic Analysis of the UK MRC (Medical Research Council) MAGIC Trial: Association of Polymorphisms with Toxicity and Survival in Patients Treated with Perioperative Epirubicin, Cisplatin, and 5-fluorouracil (ECF) Chemotherapy.PMID 28972045Read ↗

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